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Experiments

nmr logoPulse sequences are available for assigning, structural analysis  and screening of proteins, lipids, nucleic acids and oligosaccharides, metabolic profiling and DNP studies of biofluids and mixtures.

The following is a list of some of the available NMR experiments.

Please inquire if you are interested in a specific experiment not listed.

Assignment: 15N-resolved for protein assignment

  • 15N-edited TOCSY
  • C(CO)NH   
  • H(CO)NH       
  • CBCA(CO)NH        
  • CBCANH     
  • (HCA)CO(CA)NH        
  • HNCA     
  • HNCA_CT       
  • HNCO       
  • HN(CA)CO       
  • HNCACB      
  • HCA(CO)N      
  • HN(CO)CA

Assignment: 13C-resolved for protein assignmnent

  • HCACO 
  • HCCH-COSY      
  • HCCH-TOCSY

Calibration of pulses

  • 13C
  • 15N

Coupling constants

  • HMQC-J

  • HNHA

Diffusion

  • DOSY

  • waterSLED

Dynamic nuclear polarization

Ligand Screening

  • SALMON
  • STD-NMR
  • waterLOGSY

Metabolomics

  • J-resolved
  • HADAMARD TOCSY

Projection Angle Reconstruction

Relaxation

  • T1 Relaxation
  • T1rho Relaxation
  • T2 Relaxation

Residual Dipolar Coupling

  • 15N-HSQC-IPAP

Structure Determination

  • NOESY, 15N-edited (2D, 3D)
  • NOESY, 13C-edited (3D, 4D)
  • ROESY

TROSY

  • TROSY, 15N-1H correlation
  • (H)CCH TROSY (3D) 
  • TROSY-NOESY (2D and 3D)
  •  HNCA (3D)
  •  HNCACB (3D)

The Varian Inc BioPack of experiments is installed on all Varian NMR systems.